Association between inflammatory cytokine polymorphisms and papillary thyroid carcinoma
Keywords:
Thyroid Neoplasms, Polymorphism, Genetic, CytokinesAbstract
Objective: To assess the association between IFNG and IL4 gene polymorphisms and CPT and their clinical characteristics Method: Blood was collected from 30 patients with CPT and 82 healthy controls. Method: Blood was collected from 30 patients with TLC and 82 healthy controls. Genotyping was performed by the qualitative PCR technique. Results were crossed with TSH and Thyroglobulin levels of patients with CPT and analyzed using the SPSS 25.0 program. The study was approved by the ethics committee under CAAE 57382416.6.0000. 0023. Results: The +874 A / T IFNG AA genotype showed a frequency of 60% in participants with CPT, in controls the genotype TA appeared in 55.6%, the significance value was p = 0.0038. Regarding IL4, the B2 / B2 genotype was the most common in both groups with significance of p = 0.271. The samples were in HW equilibrium. Regarding the median Thyroglobulin (ng / mL) and TSH (uUI / mL), the following significance values were observed respectively: p = 0.612 and p = 0.419 for IFNG and p = 0.431 and p = 0.655 for IL4. Conclusion: There was a statistical association with +874 A / T IFNG polymorphism and CPT, however there was no association between TSH and thyroglobulin levels in patients with CPT. Regarding the IL4 gene, no significance was observed between genotypic frequency and CPT and TSH and Thyroglobulin levels. The present work reinforces the need to produce more studies on the subject in order to establish if it is in fact possible to affirm if such associations (or absence of association) are in fact in the context of the CPT.
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