Risks Related to the Interactions of Medication and Food
Keywords:
Medication interaction, Food;, Risks.Abstract
The association between medication and nutrients can produce
the occurrence of undesirable interactions, allowing an increase or
decrease in the effectiveness of the medication, as well as of the nutrient.
The phenomenon of medication‑nutrient interaction can take
place before or during the gastrointestinal absorption, during the distribution
and storage in the tissues, in the biotransformation process,
or even during excretion. Therefore, the goal of this article to clarify
the dangers related to medication interactions with food, making it
possible to alert the reader about a subject that few take into account,
in spite of its importance during the treatment with medication. The
survey was conducted based on a literature review, consulting the
BIREME and SciELO databases on the period of 2009‑2013, with the
study of 20 articles. Interactions between nutrients and medication
can alter the availability, action or toxicity of each of these substances,
or of both. It is suggested that professionals may take more advanced
courses on the subject, considering that patients do not have the
knowledge of the precautions that must be followed during the treatment
with medication.
References
Oliveira GG. A Interação fármaco‑nutriente sua
importância na terapêutica. A Folha Médica 1991;
(4):137‑142.
Farhat FC, Iftoda DM, dos Santos PH. Interações
entre hipoglicemiantes orais e alimentos. Saúde
Rev. 2007;9(21):57‑62.
Gomez R, Venturini CD. Interação entre alimentos
e medicamentos. Porto Alegre: Letra e Vida; 2009.
Hammes JA, Pfuetzenreiter F, Silveira F, Koenig
A, Westphal GA. Prevalência de potenciais interações
medicamentosas droga‑droga em unidades
de terapia intensiva. Rev Bras Ter Intensiva.
;20(4):349‑54.
Domingues CG, Paraná SP. Interações dos medicamentos
com as refeições servidas na clínica de
cirurgia urológica do hospital de clínicas UFPR.
RUBS. 2005;1(4 Supl 1):31‑2.
Pronsky ZM, Fada SR, Crowe JP, Pharmd RPH. Interações
entre alimentos e drogas. In: Mahan LK,
Escott‑Stump S. Alimentos, nutrição e dietoterapia.
a ed. São Paulo: Roca; 2005. Capítulo 19.
Brunton LL, Parker KL. Pharmacokinetics and
pharmacodynamics: the dynamics of drug absorption,
pharmacogenetics, distribution, action, and
elimination. In: Brunton LL, Parker KL, Blumenthal
D, Buxton I, editors.
Brunton LL, Parker KL. Pharmacokinetics and
pharmacodynamics: the dynamics of drug absorption,
pharmacogenetics, distribution, action, and
elimination. In: Brunton LL, Parker KL, Blumenthal
D, Buxton I, editors. Goodman & Gilman’s
manual of pharmacology and therapeutics. New
York: McGraw‑Hill; 2008. p. 1‑25.
Teitelbaum D, Guenter P, Howell WH, Kochevar
ME, Roth J, Seidner DL. Definition of terms, style,
and conventions used in A.S.P.E.N. guidelines and
standards. Nutr Clin Pract. 2005;20(2):281‑5.
Roe DA. Drugs, diets and nutrition. American
Pharmacy 1978; 18(10):62‑64.
Gomez R, Venturini CD. Interação entre alimentos
e medicamentos. Porto Alegre: Letra e Vida;
Fay MA, Sheth RD, Gidal BE. Oral absorption
kinetics of levetiracetam: the effect of mixing
with food or enteral nutrition formulas. Clin Ther.
;27(5):594‑8.
Mink S, Muroi C, Seule M, Bjeljac M, Keller E.
Levetiracetam compared to valproic acid: plasma
concentration levels, adverse effects and interactions
in aneurysmal subarachnoid hemorrhage.
Clin Neurol Neurosurg. 2011;113(8):644‑8.
Roe, DA, Geriatric Nutrition. In: ROE, D.A. Therapeutic
effects of drug‑nutrient interactions in
the elderly. Journal of the American Dietetic Association
; 85(2):174‑178.
Roe DA, Drug and food interaction as they affect
the nutrition of older individuals. Aging Clinical
and Experimental Research 1993; 5(2):S51‑S53.
Toothaker RD, Welling, PG. The effect of food on
drug bioavailability. Annual Review of Pharmacology
and Toxicology 1980; 20:173‑199.
Thomas JA. Drug‑nutrient interactions. Nutrition
Reviews 1995; 53(10):271‑282.
Lourenço R. Enteral feeding: drug/nutrient interaction.
Clin Nutr. 2001;20(2):187‑93. Souich P, Caillé G, Perreault S. Influencia de los
alimentos sobre la biodisponibilidad de los medicamentos.
In: Simposio Internacional de Biodisponibilidad
de Medicamentos y coloquio SOBRE
relación Universidad e Industria, 1, 1992, Santiago
de Chile. Anais... Santiago de Chile : Universidad
de Chile, 1992. p.53‑69.
Gai MNH. Los alimentos como factor de modificación
de la absorción de medicamentos: In:
Simposio Internacional de Biodisponibilidad de
Medicamentos y Coloquio sobre relación Universidad
e Industria, 2., 1992, Santiago de Chile.
Anais. Santiago de Chile: Universidad de Chile,
p.227‑232.
Trovato A, Nuhlicek DN, Midtling JE. Drug‑nutrient
interactions. American Family Physician
; 44(5):1651‑1658.
Basile AC Fármaco e alimentos. In: seizi‑oga, I,
Aulus, C.B. (Ed.). Medicamentos e suas interações.
São Paulo : Atheneu, 1994. p.157‑188.
Welling, PG, Tse, FLS The influence of food on
absorption of antimicrobial agents. Journal of Antimicrobial
Chemotherapy, London, v.9, p.7‑27,
Harrison LI, Riedel DJ, Armstrong KE, Goldlust
MB, Ekholm BP. Effect of food on salsalate absorption.
Therapeutic Drug Monitoring 1992;
(2):87‑91.
Welling PG. Interactions affecting drug absorption.
Clinical Pharmacokinetics, Auckland 1984;
(5):404‑434.
Guyton, AC Tratado de fisiologia médica. 8.ed.
Rio de Janeiro : Guanabara Koogan, 1992. 862p.
Gomez R, Venturini CD. Interação entre alimentos
e medicamentos. Porto Alegre: Letra e Vida;
168 p.
Roe DA. Medications and nutrition in the elderly.
Primary Care 1994; 21(1):135‑147,
Roe DA Therapeutic significance of drug‑nutrient
interactions in the elderly. Pharmacological Reviews
; 36(2):109.
Anderson KE, Conney AH, Kappas A Nutritional
influences on chemical biotransformations in humans.
Nutrition Reviews 1982; 40(6):161‑171.
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