EFFECTS OF THE USE OF IMMUNOMODULATORY FORMULAS IN CLINICAL OUTCOMES OF PATIENTS SUBMITTED TO SURGERY OF GASTROINTESTINAL TRACT
Keywords:
Immunomodulator, Immunonutrition, Malnutrition, Clinical outcome, Gastrointestinal tract surgeryAbstract
This study aimed to evaluate the outcomes of patients who are candidates for elective gastrointestinal surgery after the immunomodulatory formula usage during the perioperative period. Data were collected from 117 patients who were eligible for the 43 sample, those were divided in 2 groups (Supplemented and not supplemented) which were evaluated according to the nutritional screening (NRS-2002) results, hospitalization length and infectious or non-infectious complications appearance on post-surgical of gastrointestinal elective surgery patients. The study concluded that immunomodulatory formula do have a beneficial effect in surgical patients who were classified as nutritional risk patients by the NRS-2002. This results demonstrates the importance of nutritional care as a preventive strategy against the development of malnutrition and its related losses. Concerning the presence of comorbidities, diarrhea, number of deaths and adequacy of the supplement, no significant differences were found.
References
Waitzberg DL, Caiaffa WT, Correia MI. Hospital malnutrition: the Brazilian national survey (IBRANUTRI): a study of 4000 patients. Nutrition. 2001;17(7-8):573-80.
Barker LA, Gray C, Wilson L, Thomson BN, Shedda S, Crowe TC. Preoperative immunonutrition and its effect on postoperative outcomes in well-nourished and malnourished gastrointestinal surgery patients: a randomised controlled trial. Eur J Clin Nutr. 2013;67(8):802-7.
Hubner M, Cerantola Y, Grass F, Bertrand PC, Schafer M, Demartines N. Preoperative immunonutrition in patients at nutritional risk: results of a double-blinded randomized clinical trial. European journal of clinical nutrition. 2012;66(7):850-5.
Zacharias T, Ferreira N, Carin AJ. Preoperative immunonutrition in liver resection-a propensity score matched case-control analysis. Eur J Clin Nutr. 2014;68(8):964-9.
Nascimento J.E.A CAC, Borges Correia M.I.T.D, Tavares G.M. Terapia Nutricional no Perioperatório. In: Enteral SBdNPe, editor. Projeto Diretrizes. Brasil2011.
Worthington ML, Cresci G. Immune-modulating formulas: who wins the meta-analysis race? Nutr Clin Pract. 2011;26(6):650-5.
Kondrup J, Rasmussen HH, Hamberg O, Stanga Z, Ad Hoc EWG. Nutritional risk screening (NRS 2002): a new method based on an analysis of controlled clinical trials. Clin Nutr. 2003;22(3):321-36.
Waitzberg DL, Saito H, Plank LD, Jamieson GG, Jagannath P, Hwang TL, et al. Postsurgical infections are reduced with specialized nutrition support. World J Surg. 2006;30(8):1592-604.
Cerantola Y, Grass F, Cristaudi A, Demartines N, Schafer M, Hubner M. Perioperative nutrition in abdominal surgery: recommendations and reality. Gastroenterol Res Pract. 2011;2011:739347.
Giger-Pabst U, Lange J, Maurer C, Bucher C, Schreiber V, Schlumpf R, et al. Short-term preoperative supplementation of an immunoenriched diet does not improve clinical outcome in well-nourished patients undergoing abdominal cancer surgery. Nutrition. 2013;29(5):724-9.
Mizock BA, Sriram K. Perioperative immunonutrition. Expert Rev Clin Immunol. 2011;7(1):1-3.
Calder PC. Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology? Br J Clin Pharmacol. 2013;75(3):645-62.
Sultan J, Griffin SM, Di Franco F, Kirby JA, Shenton BK, Seal CJ, et al. Randomized clinical trial of omega-3 fatty acid-supplemented enteral nutrition versus standard enteral nutrition in patients undergoing oesophagogastric cancer surgery. Br J Surg. 2012;99(3):346-55.
Weiss G, Meyer F, Matthies B, Pross M, Koenig W, Lippert H. Immunomodulation by perioperative administration of n-3 fatty acids. Br J Nutr. 2002;87 Suppl 1:S89-94.
Kemen M, Senkal M, Homann HH, Mumme A, Dauphin AK, Baier J, et al. Early postoperative enteral nutrition with arginine-omega-3 fatty acids and ribonucleic acid-supplemented diet versus placebo in cancer patients: an immunologic evaluation of Impact. Crit Care Med. 1995;23(4):652-9.
Senkal M, Mumme A, Eickhoff U, Geier B, Spath G, Wulfert D, et al. Early postoperative enteral immunonutrition: clinical outcome and cost-comparison analysis in surgical patients. Crit Care Med. 1997;25(9):1489-96.
Marik PE, Zaloga GP. Immunonutrition in high-risk surgical patients: a systematic review and analysis of the literature. JPEN J Parenter Enteral Nutr. 2010;34(4):378-86.
Cerantola Y, Hubner M, Grass F, Demartines N, Schafer M. Immunonutrition in gastrointestinal surgery. Br J Surg. 2011;98(1):37-48.
Gomez Sanchez MB, Garcia-Talavera Espin NV, Sanchez Alvarez C, Zomeno Ros AI, Hernandez MN, Gomez Ramos MJ, et al. [Perioperative nutritional support in patients with colorectal neoplasms]. Nutricion hospitalaria. 2010;25(5):797-805.
Gomez Sanchez MB, Garcia Talavera Espin NV, Monedero Saiz T, Sanchez Alvarez C, Zomeno Ros AI, Nicolas Hernandez M, et al. [Evaluation of perioperative nutritional therapy in patients with gastrointestinal tract neoplasms]. Nutricion hospitalaria. 2011;26(5):1073-80.
Song GM, Tian X, Liang H, Yi LJ, Zhou JG, Zeng Z, et al. Role of Enteral Immunonutrition in Patients Undergoing Surgery for Gastric Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Medicine. 2015;94(31):e1311.
Osland E, Hossain MB, Khan S, Memon MA. Effect of timing of pharmaconutrition (immunonutrition) administration on outcomes of elective surgery for gastrointestinal malignancies: a systematic review and meta-analysis. JPEN Journal of parenteral and enteral nutrition. 2014;38(1):53-69.
Daly JM, Lieberman MD, Goldfine J, Shou J, Weintraub F, Rosato EF, et al. Enteral nutrition with supplemental arginine, RNA, and omega-3 fatty acids in patients after operation: immunologic, metabolic, and clinical outcome. Surgery. 1992;112(1):56-67.
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