Association of genetic polymorphism in the BCL2 gene in/with Hemorrhagic Stroke/Aneurysm

Authors

  • Izabel Cristina Rodrigues da Silva
  • Anyelle Stephane Nascimento de Lima
  • Caroline Ferreira Fratelli
  • Daniel Oliveira Freire
  • Luzitano Brandão Ferreira
  • Hélia Carla Souza

Keywords:

Genetic polymorphism, Stroke, Bcl-2 genes

Abstract

Objective: Verify the distribution of the BCL2 gene polymorphism (rs1801018), located in its coding region, in patients with Hemorrhagic Stroke (HS)/Aneurysm (A). Furthermore, to associate this polymorphism with the HS/A clinical manifestations. Method: The study was conducted with 158 research participants and the groups matched by sex and age. Genotyping was done by the PCR-RFLP technique. After calculating the allele and genotype frequencies of each group, appropriate statistical tests were performed for each comparison type with the adopted significance level of 5%. Results: The data indicated that the frequency of the genotypes showed a statistically significant difference between the case and control group, and the ala43ala genotype was found in most participants in both groups. Conclusion: The presence of the mutant allele (trh) was observed as a protective factor for HS/A. However, studies in other populations should be performed to obtain a better understanding of this disease.

References

Nettina SM. Práticas da enfermagem. Rio de Janeiro: Guanabara Koogan; 2014.

Lopes LF. PErfil dos pacientes com aneurisma cerebral em um instituto de neurologia no município de porto velho - rondônia. Centro Univrersitário São Lucas. 2018.

Bath PMW, Krishnan K. Interventions for deliberately altering blood pressure in acute stroke. Cochrane Database Syst Rev. 2014;2014(10).

Botelho T de S, Neto CDM, de Araújo FLC, de Assis SC. Epidemiologia do Acidente Vascular Cerebral no Brasil. Temas de saúde. 2016;16(2):1–18.

Siddiqui WA, AHAD A, Ahsan H. No TitleThe mystery of BCL2 family: Bcl-2 proteins and apoptosis. Arch Toxicol. 2015;89:289–317.

NCBI. BCL2 BCL2 apoptosis regulator [ Homo sapiens (human) ]. 2020.

Simani L, Naderi N, Khodagholi F, Mehrpour M, Nasoohi S. Association of Long-Term Atorvastatin with Escalated Stroke-Induced Neuroinflammation in Rats. Jounal Mol Neurosci. 2016;61.

Almeida SRM. Análise epidemiológica do acidente vascular cerebral no Brasil. Rev Neurociencias. 2012;20(4):481–2.

Carvalho VP, Ribeiro HLS, da Rocha BVE, Barcelos KA, de Andrade FV, Vasconcelos GR, et al. Perfil clínico-epidemiológico de pacientes com acidente vascular cerebral. Rev Saúde e Desenvolv. 2019;13(2011):50–61.

Alves CL, de Santana DS, Aoyama E de A. Acidente vascular encefálico em adultos jovens com enfase nos fatores de risco. ReBIS Rev Bras Interdiscip Saúde. 2020;2:1–6.

Cardoso M. O AVC no jovem adulto. Quais são as causas? [Internet]. 2017. Available from: https://lifestyle.sapo.ao/saude/saude-e-medicina/artigos/o-avc-no-jovem-adulto-quais-sao-as-causas

Avetyan D, Arakelyan A, Mkrtchyan G. Association of Bax and Bcl-2 Functional Polymorphisms and Protein Levels with Posttraumatic Stress Disorder. J Biosci Med. 2018;06(02):23–32.

Eskander EF, Abd-Rabou AA, Mohamed MS, Yahya SMM, Shaker OG. Does HCV patients who have BCL2 43Ala genotype and normal GH1 levels can achieve response to IFN based therapy? Indian J Clin Biochem. 2012;27(4):344–50.

Eun YG, Hong IK, Kim SK, Park HK, Kwon S, Chung DH, et al. A polymorphism (rs1801018, Thr7Thr) of BCL2 is associated with papillary thyroid cancer in Korean population. Clin Exp Otorhinolaryngol. 2011;4(3):149–54.

Jain M, Kumar S, Lal P, Tiwari A, Ghoshal UC, Mittal B. Role of BCL2 (ala43thr), CCND1 (G870A) and FAS (A-670G) polymorphisms in modulating the risk of developing esophageal cancer. Cancer Detect Prev. 2007;31(3):225–32.

Ministério da Saúde. Aneurisma [Internet]. Biblioteca Virtual em Saúde. 2018. Available from: http://bvsms.saude.gov.br/dicas-em-saude/2795-aneurisma

Sociedade Brasileira de Doenças Cerebrovasculares. Acidente Vascular Cerebral [Internet]. Sociedade Brasileira de Doenças Cerebrovasculares. Available from: http://www.sbdcv.org.br/publica_avc.asp

Sociedade Brasileira de Diabetes. Diretrizes Sociedade Brasileira de Diabetes 2019 -2020. 2019.

Xiang J, Ma D, Snyder K V., Levy EI, Siddiqui AH, Meng H. Increasing Flow Diversion for Cerebral Aneurysm Treatment Using a Single Flow Diverter. Neurosurgery. 2014;75(3):286–94.

Downloads

Published

2020-03-02

How to Cite

Silva, I. C. R. da, Lima, A. S. N. de, Fratelli, C. F., Freire, D. O., Ferreira, L. B., & Souza, H. C. (2020). Association of genetic polymorphism in the BCL2 gene in/with Hemorrhagic Stroke/Aneurysm. Revista De Divulgação Científica Sena Aires, 9(1), 118–124. Retrieved from https://rdcsa.emnuvens.com.br/revista/article/view/631

Issue

Vol. 9 No. 1 (2020): REVISA

Section

Original Paper

License

Copyright (c) 2025 Revista de Divulgação Científica Sena Aires

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

  • Atribuição — Você deve dar o crédito apropriado, prover um link para a licença e indicar se mudanças foram feitas. Você deve fazê-lo em qualquer circunstância razoável, mas de nenhuma maneira que sugira que o licenciante apoia você ou o seu uso.

  • Sem restrições adicionais — Você não pode aplicar termos jurídicos ou medidas de caráter tecnológico que restrinjam legalmente outros de fazerem algo que a licença permita.