Evaluation of the TP53 Arg72Pro gene polymorphism and its relationship with hemorrhagic stroke in Brazilian patients
Keywords:
Genes p53, Stroke, Genetic, PolymorphismAbstract
Objective: to investigate the association between the TP53 Arg72Pro polymorphism in patients diagnosed with hemorrhagic stroke (HS) or intracerebral aneurysm in a sample from Distrito Federal. Method: This was a case-control study, with 162 individuals equally divided into groups, with notes on the clinical characteristics of the medical record and analysis of genotyping using the PCR strategy. Genotype frequencies were estimated by direct counting. The level of significance adopted was 5%.Results: we found that the presence of the Arg allele of the TP53 Arg72Pro polymorphism acted as a risk factor for the occurrence of HS/intracerebral aneurysm. The presence of the Arg/Arg genotype increased the risk for poor prognosis (ERM> 3) in patients with HS/aneurysm (P <0.01; OR = 6.07). There was no statistical association between SAH, diabetes, smoking and alcohol consumption and the presence of the TP53 Arg72Pro polymorphism in the studied group. Conclusion: It was concluded that the presence of the Arg allele of the TP53 Arg72Pro polymorphism is associated with an increased risk of occurring HS/intracerebral aneurysm.
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