IL1B - 511 gene polymorphism (rs16944) in Brazilian patients diagnosed with haemorrhagic stroke

Authors

  • Izabel Cristina Rodrigues da Silva
  • Gilson Luiz de Carvalho Lopes Filho
  • Aline Ribeiro Barros
  • Helia Carla Souza
  • Daniel Oliveira Freire
  • Luzitano Brandão Ferreira

Keywords:

Interleukin-1, HS, Genetic polymorphism

Abstract

Objective: To assess the possible relationship between IL1B (-511 C / T) polymorphism and the prognosis of HS. Method: To evaluate this questioning, we used a sample of 81 individuals diagnosed with HS, who underwent analysis of the IL1B-511 C / T polymorphism by the PCR-RFLP technique. Statistical analysis adopted a significance level of 5%. Results: Research has shown that the presence of CC or CT / TT genotypes does not result in a statistical association between IL1B polymorphism and the appearance of HS (P = 0.174). Conclusion: The study demonstrated that C and T variation in rs16944 gene polymorphism is not associated with the selected clinical aspects. It also showed no statistical association with disease manifestation and genotypic variation.

References

Malta DC, Silva Jr JB da. O Plano de Ações Estratégicas para o Enfrentamento das Doenças Crônicas Não Transmissíveis no Brasil e a definição das metas globais para o enfrentamento dessas doenças até 2025: uma revisão. Epidemiol e Serviços Saúde [Internet]. 2013 Mar;22(1):151–64. Available from: http://scielo.iec.pa.gov.br/scielo.php?script=sci_arttext&pid=S1679-49742013000100016&lng=en&nrm=iso&tlng=en

World Health Organization. Global status report on noncommunicable diseases 2014 - Global Target 7: Halth the rise in diabetes and obesity [Internet]. 2014. Available from: http://www.who.int/nmh/publications/ncd-status-report-2014/en/

Porcello Marrone LC, Diogo LP, de Oliveira FM, Trentin S, Scalco RS, de Almeida AG, et al. Risk Factors among Stroke Subtypes in Brazil. J Stroke Cerebrovasc Dis [Internet]. 2013 Jan;22(1):32–5. Available from: https://linkinghub.elsevier.com/retrieve/pii/S1052305711001509

Hao Y, Ding J, Hong R, Bai S, Wang Z, Mo C, et al. Increased interleukin-18 level contributes to the development and severity of ischemic stroke. Aging (Albany NY) [Internet]. 2019 Sep 16;11(18). Available from: http://www.aging-us.com/article/102253/text?_escaped_fragment_=

RIBEIRO K, NEVES R, BRITO G, MORAIS J, LUCENA E, MEDEIROS J, et al. Perfil de Usuários Acometidos por Acidente Vascular Cerebral Adscritos à Estratégia Saúde da Família em uma Capital do Nordeste do Brasil. Rev Bras Ciências da Saúde [Internet]. 2012 Jul 30;16(2):35–44. Available from: http://periodicos.ufpb.br/ojs2/index.php/rbcs/article/view/16433/9522

Wu X, Luo X, Zhu Q, Zhang J, Liu Y, Luo H, et al. The Roles of Thrombospondins in Hemorrhagic Stroke. Biomed Res Int [Internet]. 2017;2017:1–8. Available from: https://www.hindawi.com/journals/bmri/2017/8403184/

Falcão CH, Falcão ALE, Ulhoa A, Rezende MT, Salgado CG, Malheiros WG, et al. Trombólise intra-arterial associada a angioplastia adjunta na fase aguda do acidente vascular cerebral isquêmico. Rev Bras Cardiol Invasiva [Internet]. 2010;18(3):263–72. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2179-83972010000300007&lng=pt&nrm=iso&tlng=en

Ye L, Gao L, Cheng H. Inflammatory Profiles of the Interleukin Family and Network in Cerebral Hemorrhage. Cell Mol Neurobiol [Internet]. 2018 Oct 19;38(7):1321–33. Available from: http://link.springer.com/10.1007/s10571-018-0601-x

Gorący, Kaczmarczyk, Ciechanowicz, Lewandowska, Jakubiszyn, Bodnar, et al. Polymorphism of Interleukin 1B May Modulate the Risk of Ischemic Stroke in Polish Patients. Medicina (B Aires) [Internet]. 2019 Sep 2;55(9):558. Available from: https://www.mdpi.com/1010-660X/55/9/558

Luotola K, Pääkkönen R, Alanne M, Lanki T, Moilanen L, Surakka I, et al. Association of Variation in the Interleukin-1 Gene Family with Diabetes and Glucose Homeostasis. J Clin Endocrinol Metab [Internet]. 2009 Nov;94(11):4575–83. Available from: https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2009-0666

Bensi G, Raugei G, Palla E, Carinci V, Buonamassa DT, Melli M. Human interleukin-1 beta gene. Gene [Internet]. 1987 Jan;52(1):95–101. Available from: https://linkinghub.elsevier.com/retrieve/pii/0378111987903982

Francisco G, Hernández C, Simó R. Serum markers of vascular inflammation in dyslipemia. Clin Chim Acta [Internet]. 2006 Jul;369(1):1–16. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0009898106000039

Ahangar AA, Saadat P, Heidari B, Taheri ST, Alijanpour S. Sex difference in types and distribution of risk factors in ischemic and hemorrhagic stroke. Int J Stroke [Internet]. 2018 Jan 31;13(1):83–6. Available from: http://journals.sagepub.com/doi/10.1177/1747493017724626

Chen R, Ovbiagele B, Feng W. Diabetes and Stroke: Epidemiology, Pathophysiology, Pharmaceuticals and Outcomes. Am J Med Sci [Internet]. 2016 Apr;351(4):380–6. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0002962915379337

Timper K, Dalmas E, Dror E, Rütti S, Thienel C, Sauter NS, et al. Glucose-Dependent Insulinotropic Peptide Stimulates Glucagon-Like Peptide 1 Production by Pancreatic Islets via Interleukin 6, Produced by α Cells. Gastroenterology [Internet]. 2016 Jul;151(1):165–79. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0016508516003048

Qi XF, Feng TJ, Yang P, Feng HY, Zhang P, Kong LY, et al. Role of inflammatory parameters in the susceptibility of cerebral thrombosis. Genet Mol Res [Internet]. 2014;13(3):6350–5. Available from: http://www.funpecrp.com.br/gmr/year2014/vol13-3/pdf/gmr3612.pdf

Community O, Project S. Características clínico-demográficas dos acidentes vasculares encefálicos de pacientes atendidos no Hospital Público Regional de Betim , MG. 2011;21(4):384–9.

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Published

2020-02-21

How to Cite

Silva, I. C. R. da, Lopes Filho, G. L. de C., Barros, A. R., Souza, H. C., Freire, D. O., & Ferreira, L. B. (2020). IL1B - 511 gene polymorphism (rs16944) in Brazilian patients diagnosed with haemorrhagic stroke . Revista De Divulgação Científica Sena Aires, 9(1), 24–29. Retrieved from https://rdcsa.emnuvens.com.br/revista/article/view/622

Issue

Vol. 9 No. 1 (2020): REVISA

Section

Original Paper

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