The influence of the MAOA gene on mental disorders of the individual

Authors

  • Elaine Viegas
  • Larissa Sousa Silva Bonasser
  • Gabriel Moura Alves Seixas
  • Izabel Cristina Rodrigues da Silva

Keywords:

MAOA, Polymorphism, Mental Disorders

Abstract

Objective: To review and discuss scientific studies that seek the association of the polymorphism of the MAOA gene, of the uVNTR type, with mental disorders in adults. Method: An integrative review was performed according to the PRISMA model. The research followed the stages of formulation of the research question, selection of reference search databases, definition of the search strategy, evaluation of the eligibility of studies, screening and selection of articles, data extraction and compilation of results. Results: We selected 12 original articles that reported the u-VNTR polymorphism and its alleles of 2, 3, 3.5, 4 and 5 repeats in the MAOA gene, and its association with psychic disorders. Conclusion: The polymorphism of the MAOA gene of the uVNTR type is related to the functionality of the MAOA enzyme, increasing or decreasing its activity, raising or decreasing the levels of dopamine, serotonin or noradrenaline, and these changes are related to several mental disorders, such as schizophrenia, depression, aggressive antisocial behaviors, anxiety, attention deficit hyperactivity disorder (ADHD),  autism spectrum disorder and other disorders related to the expression of these neurotransmitters.

References

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Published

2023-10-27

How to Cite

Viegas, E., Bonasser, L. S. S., Seixas, G. M. A., & Silva, I. C. R. da. (2023). The influence of the MAOA gene on mental disorders of the individual. Revista De Divulgação Científica Sena Aires, 12(4), 786–799. Retrieved from https://rdcsa.emnuvens.com.br/revista/article/view/115

Issue

Vol. 12 No. 4 (2023): REVISA

Section

Literature Review

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