Evolution of Rett Syndrome
Advances in teleintervention and technologies to improve social interaction
Keywords:
Rett Syndrome, Self-Help Devices, TherapeuticsAbstract
Objective: Rett Syndrome (RTT) is a neurodevelopmental disorder characterized by the regression of motor, cognitive, and communication skills. Teleintervention and assistive technologies, including Augmentative and Alternative Communication (AAC) devices and tools such as Click4all, have demonstrated efficacy in improving communication, social interaction, and adaptive functioning, especially in school settings. The active involvement of caregivers and professionals, combined with the flexibility of remote care and the use of low-cost, adaptive technologies, is essential to maximize outcomes and promote social inclusion. The integration of these strategies with conventional therapies and the continued development of customizable technologies offer promising prospects for expanding access to treatment and improving the quality of life of individuals with RTT.
References
Wang L, Hu M, Zuo MQ, Zhao J, Wu D, Huang L, et al. Mutações causadoras da síndrome de Rett comprometem a separação de fase líquido-líquido da cromatina mediada por MeCP2. Cell Res [Internet]. 2020;30(5):393–407. Disponível em: http://dx.doi.org/10.1038/s41422-020-0288-7
Sandweiss AJ, Brandt VL, Zoghbi HY. Avanços na compreensão da síndrome de Rett e da síndrome de duplicação MECP2: perspectivas para terapias futuras. Lancet Neurol [Internet]. 2020;19(8):689–98. Disponível em: http://dx.doi.org/10.1016/S1474-4422(20)30217-9
Bekteshi S, Konings M, Karlsson P, Van Criekinge T, Dan B, Monbaliu E. Teleintervenção para usuários de dispositivos de comunicação aumentativa e alternativa: uma revisão sistemática. Dev Med Child Neurol [Internet]. 2023;65(2):171–84. Disponível em: http://dx.doi.org/10.1111/dmcn.15387
Zito A, Lee JT. Variable expression of MECP2, CDKL5, and FMR1 in the human brain: Implications for gene restorative therapies. Proc Natl Acad Sci U S A [Internet]. 2024;121(9):e2312757121. Disponível em: http://dx.doi.org/10.1073/pnas.2312757121
Caprì T, Dovigo L, Semino M, Lotan M, Mohammadhasani N, Zamarra G, et al. Use of a low-tech tool in the improvement of social interaction of patients with Rett Syndrome: an observational study. Front Public Health [Internet]. 2024;12:1353099. Disponível em: http://dx.doi.org/10.3389/fpubh.2024.1353099
Percy AK, Benke TA, Marsh ED, Neul JL. Rett syndrome: The Natural History Study journey. Ann Child Neurol Soc [Internet]. 2024;2(3):189–205. Disponível em: http://dx.doi.org/10.1002/cns3.20086
Fabio RA, Semino M, Giannatiempo S, Caprì T, Iannizzotto G, Nucita A. Comparing advanced with basic telerehabilitation technologies for patients with Rett syndrome-A pilot study on behavioral parameters. Int J Environ Res Public Health [Internet]. 2022;19(1):507. Disponível em: http://dx.doi.org/10.3390/ijerph19010507
Simacek J, Dimian AF, McComas JJ. Communication intervention for young children with severe neurodevelopmental disabilities via telehealth. J Autism Dev Disord [Internet]. 2017;47(3):744–67. Disponível em: http://dx.doi.org/10.1007/s10803-016-3006-z
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