Exosomes as emerging therapeutic platforms in the treatment of glioblastoma multiforme:

advances and perspectives

Authors

  • Ihury Jhonson Evangelista Alves de Lima1
  • Elisa Mundim dos Santos Nunes Rosa
  • Genival José da Silva Neto
  • Gabriela Gonçalves Magalhães
  • Sofia Souza Bordignon
  • Nayane Peixoto Soares

Keywords:

exosomes, glioblastoma multiforme, nanotechnology, innovative therapies, targeted delivery

Abstract

Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor, with poor survival and limited response to standard therapies. Exosomes have emerged as promising platforms due to their biocompatibility, ability to cross the blood-brain barrier, and deliver therapeutic agents like RNAs, drugs, and proteins. This systematic review analyzed 15 studies (2015–2025), involving clinical and preclinical models. Findings showed that exosomes reduce tumor growth, induce apoptosis, and inhibit angiogenesis, outperforming free-form treatments. Despite their potential, challenges remain in production, scalability, and clinical safety. Exosomes offer an innovative and promising strategy for GBM treatment.

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Published

2026-02-01

How to Cite

Lima1, I. J. E. A. de, Rosa, E. M. dos S. N., Silva Neto, G. J. da, Magalhães, G. G., Bordignon, S. S., & Soares, N. P. (2026). Exosomes as emerging therapeutic platforms in the treatment of glioblastoma multiforme:: advances and perspectives. Revista De Divulgação Científica Sena Aires, 15(Esp.1), 98–104. Retrieved from https://rdcsa.emnuvens.com.br/revista/article/view/1049

Issue

Vol. 15 No. Esp.1 (2026): REVISA-Número Especial- Congresso Interdisciplinar da Área Médica

Section

Literature Review

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Copyright (c) 2026 Revista de Divulgação Científica Sena Aires

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