EFFECTS OF THE USE OF IMMUNOMODULATORY FORMULAS IN SURGICAL PATIENTS WITH GASTROINTESTINAL TRACT CANCER

Authors

  • Simone Gonzaga do Carmo
  • Renata Costa Fortes

Keywords:

Enteral nutrition, Immunonutrition, Immunological factors, Gastrointestinal neoplasms, Elective surgical procedures

Abstract

We aimed to investigate the effects of immunomodulatory formulas usage in surgical patients with gastrointestinal cancer. It is a integrative review in which the following descriptors were used: “enteral nutrition”, “surgery”, “gastrointestinal neoplasms”, “arginine”, “fatty acids, ômega-3”, “glutamine”, those were combined with Boolean operators “and” and “or” in indexed databases. Furthermore, 460 journals were found using these combinations, from those, 19 articles were selected. These articles emphasize the importance of immunomodulatory formula usage in surgical and oncological patients at specific periods due to its beneficial effects on the patients nutritional status and immune.

References

Giger-Pabst U, Lange J, Maurer C, Bucher C, Schreiber V, Schlumpf R, et al. Short-term preoperative supplementation of an immunoenriched diet does not improve clinical outcome in well-nourished patients undergoing abdominal cancer surgery. Nutrition. 2013;29(5):724-9.

Hubner M, Cerantola Y, Grass F, Bertrand PC, Schafer M, Demartines N. Preoperative immunonutrition in patients at nutritional risk: results of a double-blinded randomized clinical trial. Eur J Clin Nutr. 2012;66(7):850-5.

Klek S, Sierzega M, Szybinski P, Szczepanek K, Scislo L, Walewska E, et al. The immunomodulating enteral nutrition in malnourished surgical patients - a prospective, randomized, double-blind clinical trial. Clin Nutr. 2011;30(3):282-8.

Gomez Sanchez MB, Garcia-Talavera Espin NV, Sanchez Alvarez C, Zomeno Ros AI, Hernandez MN, Gomez Ramos MJ, et al. Perioperative nutritional support in patients with colorectal neoplasms. Nutricion hospitalaria. 2010;25(5):797-805.

Zhang Y, Gu Y, Guo T, Li Y, Cai H. Perioperative immunonutrition for gastrointestinal cancer: a systematic review of randomized controlled trials. Surg Oncol. 2012;21(2):e87-95.

Mauskopf JA, Candrilli SD, Chevrou-Severac H, Ochoa JB. Immunonutrition for patients undergoing elective surgery for gastrointestinal cancer: impact on hospital costs. World J Surg Oncol. 2012;10:136.

Calder PC. Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology? Br J Clin Pharmacol. 2013;75(3):645-62.

Gomez Sanchez MB, Garcia Talavera Espin NV, Monedero Saiz T, Sanchez Alvarez C, Zomeno Ros AI, Nicolas Hernandez M, et al. Evaluation of perioperative nutritional therapy in patients with gastrointestinal tract neoplasms. Nutr Hosp. 2011;26(5):1073-80.

Song GM, Tian X, Liang H, Yi LJ, Zhou JG, Zeng Z, et al. Role of Enteral Immunonutrition in Patients Undergoing Surgery for Gastric Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Medicine. 2015;94(31):e1311.

Sultan J, Griffin SM, Di Franco F, Kirby JA, Shenton BK, Seal CJ, et al. Randomized clinical trial of omega-3 fatty acid-supplemented enteral nutrition versus standard enteral nutrition in patients undergoing oesophagogastric cancer surgery. Br J Surg. 2012;99(3):346-55.

Osland E, Hossain MB, Khan S, Memon MA. Effect of timing of pharmaconutrition (immunonutrition) administration on outcomes of elective surgery for gastrointestinal malignancies: a systematic review and meta-analysis. JPEN Journal of parenteral and enteral nutrition. 2014;38(1):53-69.

Zhao H, Zhao H, Wang Y, Jing H, Ding Q, Xue J. Randomized clinical trial of arginine-supplemented enteral nutrition versus standard enteral nutrition in patients undergoing gastric cancer surgery. J Cancer Res Clin Oncol. 2013;139(9):1465-70.

Wei Z, Wang W, Chen J, Yang D, Yan R, Cai Q. A prospective, randomized, controlled study of omega-3 fish oil fat emulsion-based parenteral nutrition for patients following surgical resection of gastric tumors. Nutr J. 2014;13:25.

Kang K, Shu XL, Zhang YS, Liu XL, Zhao J. Effect of glutamine enriched nutrition support on surgical patients with gastrointestinal tumor: a meta-analysis of randomized controlled trials. Chin Med J (Engl). 2015;128(2):245-51.

Sorensen LS, Thorlacius-Ussing O, Schmidt EB, Rasmussen HH, Lundbye-Christensen S, Calder PC, et al. Randomized clinical trial of perioperative omega-3 fatty acid supplements in elective colorectal cancer surgery. Br J Surg. 2014;101(2):33-42.

Long H, Yang H, Lin Y, Situ D, Liu W. Fish oil-supplemented parenteral nutrition in patients following esophageal cancer surgery: effect on inflammation and immune function. Nutr Cancer. 2013;65(1):71-5.

Chevrou-Severac H, Pinget C, Cerantola Y, Demartines N, Wasserfallen JB, Schafer M. Cost-effectiveness analysis of immune-modulating nutritional support for gastrointestinal cancer patients. Clin Nutr. 2014;33(4):649-54.

Marano L, Porfidia R, Pezzella M, Grassia M, Petrillo M, Esposito G, et al. Clinical and immunological impact of early postoperative enteral immunonutrition after total gastrectomy in gastric cancer patients: a prospective randomized study. Ann Surg Oncol. 2013;20(12):3912-8.

Ma CJ, Wu JM, Tsai HL, Huang CW, Lu CY, Sun LC, et al. Prospective double-blind randomized study on the efficacy and safety of an n-3 fatty acid enriched intravenous fat emulsion in postsurgical gastric and colorectal cancer patients. Nutr J. 2015;14:9.

Klek S, Sierzega M, Szybinski P, Szczepanek K, Scislo L, Walewska E, et al. Perioperative nutrition in malnourished surgical cancer patients - a prospective, randomized, controlled clinical trial. Clin Nutr.2011;30(6):708-13.

Downloads

Published

2019-05-23

How to Cite

Carmo, S. G. do, & Fortes, R. C. (2019). EFFECTS OF THE USE OF IMMUNOMODULATORY FORMULAS IN SURGICAL PATIENTS WITH GASTROINTESTINAL TRACT CANCER. Revista De Divulgação Científica Sena Aires, 8(1), 96–111. Retrieved from https://rdcsa.emnuvens.com.br/revista/article/view/701

Issue

Vol. 8 No. 1 (2019): REVISA

Section

Literature Review

License

Copyright (c) 2025 Revista de Divulgação Científica Sena Aires

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

  • Atribuição — Você deve dar o crédito apropriado, prover um link para a licença e indicar se mudanças foram feitas. Você deve fazê-lo em qualquer circunstância razoável, mas de nenhuma maneira que sugira que o licenciante apoia você ou o seu uso.

  • Sem restrições adicionais — Você não pode aplicar termos jurídicos ou medidas de caráter tecnológico que restrinjam legalmente outros de fazerem algo que a licença permita.